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Patient ID
959717
Open Patient
Specimen ID
210-R
Open Specimen
Sample ID
A58
Open Sample
Tumor Grade
High grade or poorly differentiated
Tumor Content
40
%
Necrosis
0
%
Stromal
60
%
Inflammatory Cell
1+ (Low)
Pathology
Notes
Signet-ring cutaneous squamous cell carcinoma: Signet-ring cutaneous SCC is a very rare lesion. Histological examination of the whole tumor revealed irregular masses of proliferating tumor cells with invasive, atypical epidermal keratinocytes. Horn pearl cells and cells with individual keratinization were also present. Signet-ring cells were present, both at the border and throughout the tumor. Signet-ring cells are cells in which the nucleus is crescentically compressed to the cellular border, resulting in a signet-ring appearance. Signet-ring cell type is more commonly found in mucinous gastric carcinoma, although it is also present in a variety of other neoplasms including breast and pancreatic adenocarcinoma, leiomyosarcoma, liposarcoma and lymphoma.
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