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Patient ID
133474
Biological Sex
<Unknown>
Male
Female
Disease Body Location
Digestive/Gastrointestinal
OncoTree Code
IHCH
CTEP SDC Code
10004669 - Cholangiocar.- intra/extrahepatic
Diagnosis Subtype
intrahepatic
Date of Diagnosis
02/2023
Age at Diagnosis
37
Contributor
NCI PDMR Models
Contributor PDX ID
Grade/Stage
Information Available
Grade
TNM (Clinical)
Has Known
Metastatic Disease
Yes
Not Reported
Patient Notes
Tumor Grade/Stage: Stage IV, cT1b cN1 cM1; poorly differentiated
Location of known metastasis: pancreas, lungs, diaphragm, lymph nodes, ribs (thoracic vertebral and posterior)
STR Profile
Download
Germline Whole Exome Sequence Files (if available)
External Germline Whole Exome Sequence Data
A data file is available if a Download link is displayed:
Germline Whole Exome Sequencing (*.vcf)
Download
Ver:
2.0.2.14.0
Germline Whole Exome FASTQ (*.FASTQ.gz; for paired-end sequence, download both files)
Download Read1 FASTQ
Download Read2 FASTQ
Ver:
2.0.2.14.0
Limited Medical Information (provided after delinking)
Current Therapy
View
Date Regimen
Started
Standardized
Regimen
Best
Response
Number of
Cycles
Date of
Progression or
Off Therapy
Comments
Reason for
Off Therapy
No Current Therapy
NA
0
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Prior Therapies and Response
View
Date Regimen
Started
Standardized
Regimen
Best
Response
Duration
Months
Comments
01/2023
Dabrafenib, Trametinib
Disease Progression
0
01/2023
FOLFOX
Disease Progression
0
02/2023
Cisplatin, Durvalumab, Gemcitabine
Disease Progression
0
02/2023
Radiation
Non-evaluable
1
pallaitive
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Additional Patient History
Molecular
and
IHC Data
IHC: CAM 5.2+, AE1/AE3+, CK7+ (focal), CK20+ (focal), GATA3+ (weak). Ki-67 >25%; CDX2-, Melan-A-, PAX 8-; BRAF v600e mutation present
Additional
Medical
History
Final Pathology: Dx confirmed 51-75% involvement of liver and extensive necrosis.
Social History (provided after delinking)
Social History
View
Ethnicity
Race
Occupation
Has Smoked
100 Cigarettes
Total
Pack Years
Tobacco Use
History
Not Provided
White
Unknown
Yes
3.8
-
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1 - 1
Genetic Ancestry (SNPweights)
View
Source
Sequence
%European (CEU)
%East Asian (EA)
%Native and Latin American (NA)
%West African (YRI)
Inferred Ancestry
(80% cut-off)
Originator Sequence
100%
0%
0%
0%
European (CEU)
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Patient Specimen Information
View
Specimen ID
Biopsy Site
Tissue Type
Growth Curve Avail
Archived
Age at Sampling
Collection Date
215-R2
Liver [Z]
Resection
Yes
No
37
08/2023
215-R3
Pancreas
Resection
Yes
No
37
08/2023
215-R5
Diaphragm [X]
Resection
Yes
No
37
08/2023
215-R6
Lung [RLL]
Resection
Yes
No
37
08/2023
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