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NIH, National Cancer

Institute, Division of Cancer Treatment and Diagnosis (DCTD)

Specimen

Value Required

165739

Value Required

295-R

Disease Body Location

Digestive/Gastrointestinal

PAAD

10052747 - Adenocarcinoma - pancreas

Human Pathogen
Testing Summary

Negative

Resection

Tissue Collected

Pancreas

Provided Tissue Origin

Primary

Collection Date

10/2014

Age at Sampling

70

General Model Information

NGS Characterization

Able to Viably Passage
into Athymic Nude Mice?

Unknown

Mouse Strain Used
for Engraftment

NSG (NOD.Cg-Prkdc[scid]Il2rg[tm1Wjl]/SzJ)

Viable Passage
Implantation Site

Subcutaneous (flank)

MSI-Stable

A1	A2	B1	B2	C1	C2	PDX Concordance / PDM Type
A*01:01	A*01:01	B*08:01	B*57:01	C*06:02	C*07:01	6/6

PDX Metastatic in NSG?

Not Observed

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PDX Growth Curve Data (if available)

Growth Curve Analysis

View	Passage	Growth Curve	Growth Curve Notes
	0		There is a wide range in growth rates in passage 0 of this model (growth to 1000mg ranged from 69-115d). 4 of 5 models were passaged/SAC’d by day 95 resulting in appearance of significant growth rate decline after ~day 100.
	1		1 of 3 mice with significantly slower growth rate resulting in wide SD.
	2

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Consensus Genomic Variants from WES Files

Distribution Lots

View	PDM Type	Name	Max. Passage	Cryovial for PDX Generation	In Vitro Culture Material	PDX DNA Vials	PDX RNA Vials	PDX Flash- Frozen Vials
	PDX	165739-295-R	2	Available	Not Applicable	Available	Available Upon Request	Available

Sample (PDX)

View	PDM Type	Sample ID	Patient/Originating Specimen	PDX Passage	Sample Images Avail	OncoKB Gene Panel Data	Whole Exome Sequence Avail	RNASeq Avail
	PDX	AM1	No	0	Yes	Yes	Yes	Yes
	PDX	AM2	No	0	Yes	Yes	Yes	Yes
	PDX	AM3	No	0	Yes	No	No	No
	PDX	AM4	No	0	Yes	No	No	No
	PDX	AM1I30	No	1	Yes	Yes	Yes	Yes
	PDX	AM2I33	No	1	Yes	Yes	Yes	Yes
	PDX	AM3IA7	No	1	Yes	Yes	Yes	Yes
	PDX	AM4IJ6	No	1	Yes	Yes	Yes	Yes
	Patient/Originator Specimen	ORIGINATOR	Yes		Yes	Yes	Yes	Yes

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