Sample Editor (PDX or In Vitro Culture)

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NIH, National Cancer

Institute, Division of Cancer Treatment and Diagnosis (DCTD)

Sample

787684

078-R

Value Required

E1CQ71

Disease Body Location

Gynecologic

EOV

10033159 - Ovarian epithelial cancer

Value Required

PDX

Resection

Patient/Originating
Specimen

Passage of this Sample

1

Sample
Notes

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Pathology Data (if available)

Pathology Data

View	Tumor Grade	Tumor Content	Necrosis	Stromal	Inflammatory Cells	Low Magnification Image	High Magnification Image
	Low grade or well differentiated	45%	50%	5%	Absent/No Inflammation

Genomic Analysis

External Genetic Analysis Data

A data file is available if a Download link is displayed:

2.0.2.51.0

Download Read1 FASTQ

Download Read2 FASTQ

2.0.2.51.0

Download Read1 FASTQ

Download Read2 FASTQ

2.0.2.21.0

Download RSEM (genes)

Download RSEM (isoforms)

2.0.2.21.0

OncoKB Gene Panel

View	Hugo Symbol	HGVS Protein Change	Variant Allele Frequency	Total Reads	Variant Class	Oncogenicity	Predicted Functional Effect	OncoKB Version
	APC	p.S21*	0.3544	79	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	APC	p.R1114*	0.5926	135	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	APC	p.R1450*	0.3511	94	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	ARID1B	p.G966S	0.4045	178	Missense_Mutation	Likely Oncogenic	Unknown	v4.6
	ARID4B	p.E868*	0.4302	86	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	ATM	p.M557Nfs*9	0.2069	58	Frame_Shift_Ins	Likely Oncogenic	Likely Loss-of-function	v4.6
	ATR	p.R1368*	0.3292	161	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	BRAF	p.K499N	0.5600	25	Missense_Mutation	Likely Oncogenic	Likely Gain-of-function	v4.6
	BRCA2	p.E2121*	0.5122	41	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	CD58	p.E53*	0.7073	41	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	CHEK2	p.E321*	0.5273	110	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	CHEK2	p.Y297*	0.4412	34	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	CHEK2	p.E70*	0.5417	72	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	CTCF	p.E133*	0.4400	125	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	DTX1	p.R397*	0.4088	159	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	EED	p.R441*	0.5926	27	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	EZH2	p.R207Q	0.6043	187	Missense_Mutation	Inconclusive	Inconclusive	v4.6
	FAT1	p.X3881_splice	0.4437	151	Splice_Site	Likely Oncogenic	Likely Loss-of-function	v4.6
	FAT1	p.R2556*	0.7419	62	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	FAT1	p.E1292*	0.6420	176	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	FGFR2	p.R203H	0.6207	87	Missense_Mutation	Likely Neutral	Likely Neutral	v4.6
	FH	p.E404*	0.4130	46	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	FUBP1	p.R344*	0.2923	65	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	INHA	p.E77*	0.2454	269	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	KMT2A	p.N3762Efs*9	0.2034	59	Frame_Shift_Ins	Likely Oncogenic	Likely Loss-of-function	v4.6
	KMT2D	p.R3982*	0.3770	122	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	MAP3K1	p.E1441*	0.5918	49	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	MITF	p.E327*	0.3902	41	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	MSH2	p.E278*	0.2206	68	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	NCOR1	p.E1346*	0.4386	171	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	NF1	p.R440*	0.6333	90	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	NOTCH1	p.V1671I	0.4054	74	Missense_Mutation	Likely Oncogenic	Likely Gain-of-function	v4.6
	PBRM1	p.R1160*	0.5294	34	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	PBRM1	p.R710*	0.7396	96	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	PIK3R1	p.R162*	0.4641	153	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	PIK3R1	p.R348*	0.6064	188	Nonsense_Mutation	Oncogenic	Loss-of-function	v4.6
	PMS2	p.R563*	0.4943	174	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	POLE	p.P286R	0.4773	88	Missense_Mutation	Likely Oncogenic	Loss-of-function	v4.6
	PTEN	p.E7*	0.4318	88	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	PTEN	p.R173C	0.4400	25	Missense_Mutation	Likely Oncogenic	Loss-of-function	v4.6
	PTPRD	p.S431L	0.2979	47	Missense_Mutation	Likely Oncogenic	Unknown	v4.6
	PTPRT	p.R936*	0.4959	123	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	PTPRT	p.E166*	0.3913	46	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	RAD51B	p.E198*	0.4815	27	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	RASA1	p.E722*	0.3714	70	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	RASA1	p.R1010*	0.3878	98	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	RB1	p.E137*	1.0000	29	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	RB1	p.S648*	0.5117	213	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	SESN3	p.S308*	0.5000	38	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	SH2D1A	p.E119*	1.0000	5	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	SHQ1	p.E109*	0.3333	18	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	SPOP	p.R240*	0.3647	85	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	TBX3	p.X289_splice	0.5349	172	Splice_Site	Likely Oncogenic	Likely Loss-of-function	v4.6
	TP53BP1	p.E288*	0.5028	181	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	TSC1	p.E485*	0.4444	18	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	XPO1	p.R749Q	0.1574	216	Missense_Mutation	Likely Oncogenic	Likely Gain-of-function	v4.6
	XPO1	p.E571K	0.2250	80	Missense_Mutation	Oncogenic	Gain-of-function	v4.6
	ZFHX3	p.E2975*	0.5181	166	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	ZFHX3	p.R2668*	0.5979	189	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	ARHGAP35	p.E371*	1.0000	192	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	DOT1L	p.A1003T	0.5515	524	Missense_Mutation	Likely Oncogenic	Likely Gain-of-function	v4.6
	RAD17	p.R301*	0.6087	23	Nonsense_Mutation	Likely Oncogenic	Loss-of-function	v4.6
	LRP1B	p.E2849*	0.2231	130	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	LRP1B	p.X115_splice	0.2286	35	Splice_Site	Likely Oncogenic	Likely Loss-of-function	v4.6

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