Sample Editor (PDX or In Vitro Culture)

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NIH, National Cancer

Institute, Division of Cancer Treatment and Diagnosis (DCTD)

Sample

787684

078-R

Value Required

E1CQ70W28

Disease Body Location

Gynecologic

EOV

10033159 - Ovarian epithelial cancer

Value Required

PDX

Resection

Patient/Originating
Specimen

Passage of this Sample

2

Sample
Notes

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Pathology Data (if available)

Pathology Data

View	Tumor Grade	Tumor Content	Necrosis	Stromal	Inflammatory Cells	Low Magnification Image	High Magnification Image
	Intermediate grade or moderately differentiated	40%	55%	5%	Absent/No Inflammation

Genomic Analysis

External Genetic Analysis Data

A data file is available if a Download link is displayed:

2.0.2.51.0

Download Read1 FASTQ

Download Read2 FASTQ

2.0.2.51.0

Download Read1 FASTQ

Download Read2 FASTQ

2.0.2.21.0

Download RSEM (genes)

Download RSEM (isoforms)

2.0.2.21.0

OncoKB Gene Panel

View	Hugo Symbol	HGVS Protein Change	Variant Allele Frequency	Total Reads	Variant Class	Oncogenicity	Predicted Functional Effect	OncoKB Version
	APC	p.S21*	0.3756	213	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	APC	p.R1114*	0.4314	255	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	APC	p.R1450*	0.5389	193	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	ARID1B	p.G966S	0.4454	339	Missense_Mutation	Likely Oncogenic	Unknown	v4.6
	ARID4B	p.E868*	0.4118	170	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	ATM	p.M557Nfs*9	0.3373	169	Frame_Shift_Ins	Likely Oncogenic	Likely Loss-of-function	v4.6
	ATR	p.R1368*	0.2829	509	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	BRAF	p.K499N	0.4828	29	Missense_Mutation	Likely Oncogenic	Likely Gain-of-function	v4.6
	BRCA2	p.E2121*	0.6835	79	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	CD58	p.E53*	0.6226	53	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	CHEK2	p.E321*	0.4901	202	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	CHEK2	p.Y297*	0.3571	28	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	CHEK2	p.E70*	0.6198	121	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	CTCF	p.E133*	0.4550	200	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	DTX1	p.R397*	0.2419	124	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	EED	p.R441*	0.5698	86	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	EZH2	p.R207Q	0.4964	415	Missense_Mutation	Inconclusive	Inconclusive	v4.6
	FAT1	p.X3881_splice	0.4332	187	Splice_Site	Likely Oncogenic	Likely Loss-of-function	v4.6
	FAT1	p.R2556*	0.4833	120	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	FAT1	p.E1292*	0.4700	466	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	FGFR2	p.R203H	0.4929	140	Missense_Mutation	Likely Neutral	Likely Neutral	v4.6
	FH	p.E404*	0.2710	107	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	FUBP1	p.R344*	0.3898	177	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	INHA	p.E77*	0.2919	161	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	KMT2D	p.R3982*	0.4405	84	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	MAP3K1	p.E1441*	0.4891	92	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	MITF	p.E327*	0.2941	68	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	MSH2	p.E278*	0.4215	121	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	NCOR1	p.E1346*	0.5040	377	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	NF1	p.E163*	0.3250	40	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	NF1	p.R440*	0.5805	267	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	NOTCH1	p.V1671I	0.4382	89	Missense_Mutation	Likely Oncogenic	Likely Gain-of-function	v4.6
	PBRM1	p.R1160*	0.7069	58	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	PBRM1	p.R710*	0.5420	131	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	PIK3R1	p.R162*	0.4088	296	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	PIK3R1	p.R348*	0.4951	307	Nonsense_Mutation	Oncogenic	Loss-of-function	v4.6
	PMS2	p.R563*	0.4474	266	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	POLE	p.P286R	0.6716	67	Missense_Mutation	Likely Oncogenic	Loss-of-function	v4.6
	PTEN	p.E7*	0.7015	67	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	PTEN	p.R173C	0.4324	37	Missense_Mutation	Likely Oncogenic	Loss-of-function	v4.6
	PTPRD	p.S431L	0.4798	198	Missense_Mutation	Likely Oncogenic	Unknown	v4.6
	PTPRT	p.R936*	0.6349	189	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	PTPRT	p.E166*	0.6373	102	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	RAD51B	p.E198*	0.4407	59	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	RASA1	p.E722*	0.4564	149	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	RASA1	p.R1010*	0.4176	261	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	RB1	p.E137*	1.0000	50	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	RB1	p.S648*	0.5511	176	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	SESN3	p.S308*	0.5963	109	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	SH2D1A	p.E119*	1.0000	15	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	SHQ1	p.E109*	0.2571	35	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	SPOP	p.R240*	0.5514	107	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	TBX3	p.X289_splice	0.7114	149	Splice_Site	Likely Oncogenic	Likely Loss-of-function	v4.6
	TP53BP1	p.E288*	0.5058	257	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	TSC1	p.E485*	0.5111	45	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	XPO1	p.R749Q	0.4944	356	Missense_Mutation	Likely Oncogenic	Likely Gain-of-function	v4.6
	XPO1	p.E571K	0.5312	160	Missense_Mutation	Oncogenic	Gain-of-function	v4.6
	ZFHX3	p.E2975*	0.4278	187	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	ZFHX3	p.R2668*	0.5062	320	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	ARHGAP35	p.E371*	1.0000	360	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	DOT1L	p.A1003T	0.5264	416	Missense_Mutation	Likely Oncogenic	Likely Gain-of-function	v4.6
	RAD17	p.R301*	0.6591	44	Nonsense_Mutation	Likely Oncogenic	Loss-of-function	v4.6
	LRP1B	p.E2849*	0.2650	351	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6

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