Sample Editor (PDX or In Vitro Culture)

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NIH, National Cancer

Institute, Division of Cancer Treatment and Diagnosis (DCTD)

Sample

787684

078-R

Value Required

E1CQ70W27W77VUEWP2M440

Disease Body Location

Gynecologic

EOV

10033159 - Ovarian epithelial cancer

Value Required

PDX

Resection

Patient/Originating
Specimen

Passage of this Sample

6

Sample
Notes

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Pathology Data (if available)

Pathology Data

View	Tumor Grade	Tumor Content	Necrosis	Stromal	Inflammatory Cells	Low Magnification Image	High Magnification Image
	Low grade or well differentiated	40%	20%	40%	2+ (Moderate)

Genomic Analysis

External Genetic Analysis Data

A data file is available if a Download link is displayed:

2.0.2.51.0

Download Read1 FASTQ

Download Read2 FASTQ

2.0.2.51.0

Download Read1 FASTQ

Download Read2 FASTQ

2.0.2.21.0

Download RSEM (genes)

Download RSEM (isoforms)

2.0.2.21.0

OncoKB Gene Panel

View	Hugo Symbol	HGVS Protein Change	Variant Allele Frequency	Total Reads	Variant Class	Oncogenicity	Predicted Functional Effect	OncoKB Version
	APC	p.S21*	0.6329	237	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	APC	p.R1114*	0.3471	412	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	APC	p.R1450*	0.6258	326	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	ARID1B	p.G966S	0.5160	405	Missense_Mutation	Likely Oncogenic	Unknown	v4.6
	ARID4B	p.E868*	0.2917	288	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	ATM	p.M557Nfs*9	0.3254	169	Frame_Shift_Ins	Likely Oncogenic	Likely Loss-of-function	v4.6
	ATR	p.R1368*	0.2884	631	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	BRAF	p.K499N	0.5111	45	Missense_Mutation	Likely Oncogenic	Likely Gain-of-function	v4.6
	BRCA2	p.E2121*	0.4490	98	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	BRIP1	p.E339*	0.2623	446	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	CD58	p.E53*	0.6792	106	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	CHEK2	p.E321*	0.2420	157	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	CHEK2	p.Y297*	0.6596	47	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	CHEK2	p.E70*	0.2936	109	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	CTCF	p.E133*	0.4154	272	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	DTX1	p.R397*	0.3333	129	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	EED	p.R441*	0.5000	80	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	EP400	p.Q2737_Q2738ins*	0.3216	171	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	EZH2	p.R207Q	0.4559	487	Missense_Mutation	Inconclusive	Inconclusive	v4.6
	FAT1	p.X3881_splice	0.3927	275	Splice_Site	Likely Oncogenic	Likely Loss-of-function	v4.6
	FAT1	p.R2556*	0.5307	179	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	FAT1	p.E1292*	0.4728	533	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	FGFR2	p.R203H	0.5103	194	Missense_Mutation	Likely Neutral	Likely Neutral	v4.6
	FH	p.E404*	0.2564	156	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	FUBP1	p.R344*	0.2830	212	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	INHA	p.E77*	0.2098	205	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	KMT2D	p.R3982*	0.3248	117	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	MAP3K1	p.E1441*	0.3932	117	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	MITF	p.E327*	0.3277	119	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	MSH2	p.E278*	0.5025	203	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	NCOR1	p.E1346*	0.4685	444	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	NF1	p.E163*	0.2500	32	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	NF1	p.R440*	0.4215	325	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	NOTCH1	p.V1671I	0.4783	69	Missense_Mutation	Likely Oncogenic	Likely Gain-of-function	v4.6
	PBRM1	p.R1160*	0.6933	75	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	PBRM1	p.R710*	0.6589	214	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	PIK3R1	p.R162*	0.5622	482	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	PIK3R1	p.R348*	0.4004	507	Nonsense_Mutation	Oncogenic	Loss-of-function	v4.6
	PMS2	p.R563*	0.4962	393	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	POLE	p.P286R	0.4835	91	Missense_Mutation	Likely Oncogenic	Loss-of-function	v4.6
	PTEN	p.E7*	0.5546	119	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	PTEN	p.R173C	0.4557	79	Missense_Mutation	Likely Oncogenic	Loss-of-function	v4.6
	PTPRD	p.S431L	0.5432	243	Missense_Mutation	Likely Oncogenic	Unknown	v4.6
	PTPRT	p.R936*	0.5314	207	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	PTPRT	p.E166*	0.5312	96	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	RAD51B	p.E198*	0.5638	94	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	RASA1	p.E722*	0.5000	196	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	RASA1	p.R1010*	0.6344	331	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	RB1	p.E137*	1.0000	78	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	RB1	p.S648*	0.5053	283	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	SESN3	p.S308*	0.5814	129	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	SH2D1A	p.E119*	1.0000	27	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	SHQ1	p.E109*	0.1887	53	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	SPOP	p.R240*	0.5161	186	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	TBX3	p.X289_splice	0.6994	173	Splice_Site	Likely Oncogenic	Likely Loss-of-function	v4.6
	TP53BP1	p.E288*	0.5311	305	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	TSC1	p.E485*	0.5526	38	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	XPO1	p.R749Q	0.4241	474	Missense_Mutation	Likely Oncogenic	Likely Gain-of-function	v4.6
	XPO1	p.E571K	0.4178	225	Missense_Mutation	Oncogenic	Gain-of-function	v4.6
	ZFHX3	p.E2975*	0.6017	241	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	ZFHX3	p.R2668*	0.4786	374	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	ARHGAP35	p.E371*	1.0000	402	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	DOT1L	p.A1003T	0.4875	521	Missense_Mutation	Likely Oncogenic	Likely Gain-of-function	v4.6
	RAD17	p.R301*	0.3243	74	Nonsense_Mutation	Likely Oncogenic	Loss-of-function	v4.6
	LRP1B	p.E2849*	0.2431	399	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.6
	LRP1B	p.X115_splice	0.3167	120	Splice_Site	Likely Oncogenic	Likely Loss-of-function	v4.6

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