Sample Editor (PDX or In Vitro Culture)

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NIH, National Cancer

Institute, Division of Cancer Treatment and Diagnosis (DCTD)

Sample

625472

104-R

Value Required

H69HC1

Disease Body Location

Digestive/Gastrointestinal

COAD

10009951 - Adenocarcinoma - colon

Value Required

PDX

Resection

Patient/Originating
Specimen

Passage of this Sample

1

Sample
Notes

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Pathology Data (if available)

Pathology Data

View	Tumor Grade	Tumor Content	Necrosis	Stromal	Inflammatory Cells	Low Magnification Image	High Magnification Image
	Intermediate grade or moderately differentiated	65%	15%	20%	1+ (Low)

Genomic Analysis

External Genetic Analysis Data

A data file is available if a Download link is displayed:

2.0.1.50.0

Download Read1 FASTQ

Download Read2 FASTQ

1.2

Download Read1 FASTQ

Download Read2 FASTQ

1.2

Download RSEM (genes)

Download RSEM (isoforms)

2.0.1.4.0

OncoKB Gene Panel

View	Hugo Symbol	HGVS Protein Change	Variant Allele Frequency	Total Reads	Variant Class	Oncogenicity	Predicted Functional Effect	OncoKB Version
	ASXL1	p.G645Wfs*12	0.0000	129	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v3.14
	ATRX	p.N633Tfs*16	0.5297	219	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v3.14
	BCOR	p.R1514*	0.7222	54	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v3.14
	BCORL1	p.M644Hfs*21	0.4861	502	Frame_Shift_Ins	Likely Oncogenic	Likely Loss-of-function	v3.14
	BCORL1	p.Q798*	0.5449	345	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v3.14
	BRAF	p.V600E	1.0000	33	Missense_Mutation	Oncogenic	Gain-of-function	v3.14
	BRCA2	p.Y1220Ifs*8	0.6438	219	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v3.14
	CASP8	p.R292W	0.4365	181	Missense_Mutation	Likely Oncogenic	Unknown	v3.14
	CCND3	p.P284L	1.0000	102	Missense_Mutation	Likely Oncogenic	Likely Gain-of-function	v3.14
	CDKN1A	p.R83Gfs*65	0.4483	203	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v3.14
	CDKN2A	p.D84N	0.3824	68	Missense_Mutation	Likely Oncogenic	Loss-of-function	v3.14
	DIS3	p.I678Ffs*59	0.3147	143	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v3.14
	EPHA3	p.E647Rfs*9	0.4766	128	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v3.14
	ESCO2	p.T254Nfs*27	0.4615	143	Frame_Shift_Ins	Likely Oncogenic	Likely Loss-of-function	v3.14
	FOXL2	p.K193Sfs*78	0.5000	144	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v3.14
	INPPL1	p.R1156Gfs*46	0.4364	55	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v3.14
	JARID2	p.A396Rfs*18	0.4695	164	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v3.14
	KMT2A	p.K3828Rfs*31	0.5097	155	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v3.14
	KMT2D	p.R5340*	0.5286	70	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v3.14
	MGA	p.D2578Tfs*10	0.4809	235	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v3.14
	MSH2	p.A230Lfs*16	0.4422	199	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v3.14
	MSH3	p.K383Rfs*32	0.4896	96	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v3.14
	PIK3CA	p.C420R	0.5891	129	Missense_Mutation	Oncogenic	Gain-of-function	v3.14
	RB1	p.R320*	0.6970	66	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v3.14
	RB1	p.R418Kfs*10	0.3333	111	Frame_Shift_Ins	Likely Oncogenic	Likely Loss-of-function	v3.14
	RIT1	p.A57D	0.2173	474	Missense_Mutation	Likely Oncogenic	Likely Gain-of-function	v3.14
	RNF43	p.P660Sfs*87	0.4889	135	Frame_Shift_Ins	Likely Oncogenic	Likely Loss-of-function	v3.14
	TET1	p.N486Ifs*6	0.4684	158	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v3.14
	TET2	p.X1395_splice	0.1600	50	Splice_Site	Likely Oncogenic	Likely Loss-of-function	v3.14

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