Sample Editor (PDX or In Vitro Culture)

Derived from passage 1 PDX material. Mouse cells were depleted from culture using magnetic beads labeled with anti-mCD9 and anti-mMHC antibodies. Determined to be a tumor by FACS analysis, QRT-PCR, and cell morphology

Tumorigenic in
NSG Mice

Spheroid Growth

Spheroid Growth
Notes

N/D

Soft Agar Growth

Soft Agar
Growth Notes

Fibroblast qRT-PCR
C1 Corr

0.02

Fibroblast qRT-PCR
C2 Corr

0.02

Fibroblast qRT-PCR
Top Hits

KRT18,FN1,KRT8,KRT17,KRT19

Images (if available)

Genomic Analysis

External Genetic Analysis Data

A data file is available if a Download link is displayed:

2.0.4.51.0

2.0.4.51.0

2.0.4.18.0

Download RSEM (genes)

Download RSEM (isoforms)

Ver:

2.0.4.18.0

OncoKB Gene Panel

Hugo Symbol	HGVS Protein Change	Variant Allele Frequency	Total Reads	Variant Class	Oncogenicity	Predicted Functional Effect	OncoKB Version
None Found	p.W292*	0.4889	135	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.27
BCOR	p.R1231Gfs*7	0.4118	459	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v4.27
BRCA1	p.K820E	0.4768	539	Missense_Mutation	Inconclusive	Inconclusive	v4.27
ERRFI1	-	0.4737	19	Splice_Site	Likely Oncogenic	Likely Loss-of-function	v4.27
FBXW7	p.R479Q	0.4397	348	Missense_Mutation	Oncogenic	Loss-of-function	v4.27
FBXW7	p.R222*	0.5321	218	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.27
LATS2	p.P473_A480dup	0.4242	33	In_Frame_Ins	Likely Oncogenic	Unknown	v4.27
MST1	p.D475Qfs*52	0.1279	344	Frame_Shift_Ins	Likely Oncogenic	Likely Loss-of-function	v4.27
NOTCH1	p.V1671I	0.3803	71	Missense_Mutation	Likely Oncogenic	Likely Gain-of-function	v4.27
ROBO1	p.R922H	0.4679	483	Missense_Mutation	Likely Oncogenic	Likely Loss-of-function	v4.27
TP53	p.R175H	1.0000	203	Missense_Mutation	Oncogenic	Loss-of-function	v4.27
CHD4	p.E139del	0.1064	94	In_Frame_Del	Inconclusive	Inconclusive	v4.27
ZMYM3	p.L85Afs*4	0.4389	303	Frame_Shift_Ins	Likely Oncogenic	Likely Loss-of-function	v4.27

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