Sample Editor (PDX or In Vitro Culture)

Hugo Symbol	HGVS Protein Change	Variant Allele Frequency	Total Reads	Variant Class	Oncogenicity	Predicted Functional Effect	OncoKB Version
None Found	p.S326Lfs*33	0.6500	140	Frame_Shift_Ins	Likely Oncogenic	Likely Loss-of-function	-
ANKRD11	p.A2265Rfs*8	0.4018	112	Frame_Shift_Ins	Likely Oncogenic	Likely Loss-of-function	-
APC	p.V452Sfs*7	0.3832	107	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	-
APC	p.T1556Nfs*3	0.4574	223	Frame_Shift_Ins	Likely Oncogenic	Likely Loss-of-function	-
BRAF	p.V600E	0.6927	179	Missense_Mutation	Oncogenic	Gain-of-function	-
FBXW7	p.R465C	0.4764	296	Missense_Mutation	Oncogenic	Loss-of-function	-
HIST1H1D	p.A186Lfs*?	0.4251	207	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	-
INHA	p.L189Cfs*2	0.5447	872	Frame_Shift_Ins	Likely Oncogenic	Likely Loss-of-function	-
KEAP1	p.F478Lfs*2	0.5178	338	Frame_Shift_Ins	Likely Oncogenic	Likely Loss-of-function	-
NOTCH3	p.K2069Rfs*16	0.4561	171	Frame_Shift_Del	Likely Oncogenic	Likely Gain-of-function	-
NOTCH3	p.X715_splice	0.4756	164	Splice_Site	Likely Oncogenic	Likely Loss-of-function	-
RAD50	p.K722Rfs*14	0.5763	236	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	-
RNF43	p.G659Vfs*41	0.5520	250	Frame_Shift_Del	Inconclusive	Inconclusive	-
TSC2	p.T1247Sfs*74	0.5020	247	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	-
BRSK1	p.H19Tfs*47	0.4242	33	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	-
ZFP36L2	p.G107Afs*80	0.4740	289	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	-
ELMSAN1	p.I659Sfs*45	0.6286	420	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	-

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