Sample Editor (PDX or In Vitro Culture)

Hugo Symbol	HGVS Protein Change	Variant Allele Frequency	Total Reads	Variant Class	Oncogenicity	Predicted Functional Effect	OncoKB Version
ATM	p.K2811Sfs*46	0.5510	49	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v7.1
ATR	p.I774Yfs*5	0.5053	95	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v7.1
BRAF	p.V600E	0.4655	58	Missense_Mutation	Oncogenic	Gain-of-function	v7.1
BRCA2	p.T3085Qfs*19	0.4400	100	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v7.1
CDKN1B	p.D63Rfs*62	0.4916	596	Frame_Shift_Ins	Likely Oncogenic	Likely Loss-of-function	v7.1
CREBBP	p.K1565Rfs*70	0.5559	349	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v7.1
EPHA7	p.X33_splice	0.5612	98	Splice_Site	Likely Oncogenic	Likely Loss-of-function	v7.1
FAT1	p.X3402_splice	0.4788	165	Splice_Site	Likely Oncogenic	Likely Loss-of-function	v7.1
FAT1	p.N126Kfs*3	0.4744	390	Frame_Shift_Ins	Likely Oncogenic	Likely Loss-of-function	v7.1
HNF1A	p.P291Qfs*51	0.4555	494	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v7.1
JAK1	p.P861Tfs*4	0.4914	291	Frame_Shift_Ins	Likely Oncogenic	Likely Loss-of-function	v7.1
KMT2D	p.Q2109Afs*46	0.4349	269	Frame_Shift_Ins	Likely Oncogenic	Likely Loss-of-function	v7.1
MSH3	p.K383Rfs*32	1.0000	104	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v7.1
PHOX2B	p.G268Afs*41	0.5000	234	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v7.1
PIK3R1	p.R461*	0.4394	66	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v7.1
PTCH1	p.Y1316Tfs*56	0.1209	215	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v7.1
PTEN	p.L57Wfs*42	0.5000	36	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v7.1
PTEN	p.K267Rfs*9	0.5125	80	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v7.1
RAD50	p.K722Rfs*14	0.5467	289	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v7.1
RNF43	p.G659Vfs*41	0.4644	323	Frame_Shift_Del	Inconclusive	Inconclusive	v7.1
RNF43	p.R117Pfs*8	0.9889	180	Frame_Shift_Ins	Likely Oncogenic	Likely Loss-of-function	v7.1
SESN2	p.Q229Rfs*18	0.5354	396	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v7.1
SPEN	p.A2105Lfs*33	0.4854	274	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v7.1
SPEN	p.P2461Hfs*15	0.4922	770	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v7.1
SPRTN	p.G222Afs*7	0.4510	337	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v7.1
TP53	p.R273C	0.5340	103	Missense_Mutation	Likely Oncogenic	Likely Loss-of-function	v7.1
ZNRF3	p.L31Rfs*91	0.6000	70	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v7.1
ZNRF3	p.G612Afs*54	0.4613	800	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v7.1
FANCL	p.Q99Rfs*17	0.5088	226	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v7.1
LRP1B	p.H4368Tfs*4	0.4372	183	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v7.1
CHD4	p.K119del	0.4835	182	In_Frame_Del	Inconclusive	Inconclusive	v7.1
CHD2	p.K1245Nfs*4	0.5258	97	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v7.1
COL2A1	p.Q36*	0.5319	47	Nonsense_Mutation	Likely Oncogenic	Likely Loss-of-function	v7.1
PTPN13	p.K285Nfs*45	0.4718	284	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v7.1
XRCC1	p.A189Lfs*44	0.4972	181	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v7.1
FANCE	p.P310Qfs*54	0.4908	273	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v7.1
HOXA11	p.I299Lfs*30	0.4680	203	Frame_Shift_Del	Likely Oncogenic	Likely Loss-of-function	v7.1

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